Methylation, Hormones & the Path to Resilience — When Your Genes Need More Support

Many people experience chronic fatigue, hormonal imbalances or heightened stress sensitivity—yet conventional lab tests often return “normal.” If you’ve been told that “everything looks normal” but still feel off, it may be time to explore what your genes are signaling.

Methylation: A Core Process with Systemic Impact

• Methylation is a fundamental cellular mechanism that influences:
• The conversion and utilization of nutrients such as folate, B12, choline and methionine
• Hormonal detoxification, especially of estrogen and histamine
• Neurotransmitter metabolism (including dopamine, serotonin, and adrenaline)
• Mitochondrial energy output, DNA repair, and immune regulation

Variants in genes such as MTHFR and COMT may influence how your body processes nutrients, manages stress, and regulates hormones—contributing to biochemical vulnerability. Fortunately, epigenetic regulation allows us to guide gene expression in a favorable direction through personalized nutrition, therapeutic lifestyle interventions, and targeted biochemical support.

Signs You May Need Methylation Support

Clients with methylation inefficiencies often present with:
• Persistent fatigue, mental fog, or fluctuating mood states
• Hormonal imbalances such as estrogen dominance, histamine overload, or disrupted menstrual cycles
• Heightened emotional reactivity, anxiety, or reduced stress tolerance
• Poor detoxification capacity or adverse reactions to supplements and medications
• Recurring migraines, fertility challenges, or nutrient malabsorption despite healthy intake

Our Precision-Based Diagnostic Framework

At DNA Care, we combine genetic and biochemical insights using an integrative, multi-layered approach:
• Genetic analysis: interpretation of SNPs in methylation, neurotransmitter, biotransformation and inflammation pathways
• Organix urine testing: functional status of methylation, mitochondria, oxidative stress and biotransformation intermediates
• GI-MAP microbiome testing: gut-brain-immune interactions and inflammatory load
• Comprehensive blood panels, including:
→ Homocysteine, SAMe, SAH
→ Active and intracellular B12, methylfolate, P5P (B6)
→ Zinc, copper, tryptophan, tyrosine
→ hs-CRP, GGT, 8-OHdG (inflammation/oxidative stress)

We contextualize these findings within your trauma history, circadian rhythm, lifestyle factors and symptom expression.

Preconception & Fertility Support

Methylation also plays a critical role in preconception and pregnancy. Impaired folate metabolism, detoxification bottlenecks, or oxidative stress may impact egg quality, implantation, and pregnancy outcomes. Supporting these pathways early can enhance fertility and promote a healthy pregnancy.

What Sets DNA Care Apart

We don’t treat gene variants—we guide people with system-based strategies that honor complexity.

Whether you’re starting from scratch or have already completed DNA testing elsewhere, we can meet you where you are. We regularly work with existing DNA profiles, helping clients make sense of their data and integrate it into a clinically meaningful, system-based care plan. At DNA Care, we translate genetic potential into clinical insight by integrating:
• Molecular diagnostics and functional lab interpretation
• Epigenetic nutrition and targeted micronutrient repletion
• Stress axis regulation (HPA-axis, vagal tone, neuroplasticity)
• Behavioral and circadian recalibration rooted in neurobiology

Our fully personalized protocols aim to restore:
• Methylation capacity and mitochondrial vitality
• Hormonal and neurotransmitter equilibrium
• Immune balance and biotransformation capacity
• Cognitive clarity and emotional resilience

Your DNA contains potential—not predetermination. We help you decode it with nuance, precision, and care.