Genova Adrenal Function Profile (Cortisol curve and DHEA) +

HPA Axis: Assessing Cortisol and DHEA Dynamics in Chronic Stress Conditions

What Is the HPA Axis and How Is It Related to Adrenal Fatigue?

The HPA axis (hypothalamic-pituitary-adrenal axis) is the communication network between your brain and endocrine system. It regulates your response to stress—whether physical, emotional, or chemical—and plays a central role in energy metabolism, mood, sleep, immune function, and hormonal balance.

When stress becomes chronic or recurrent, this axis can become dysregulated. The effects are often systemic, leading to a wide range of symptoms. Although the term adrenal fatigue is widely used, it is not a medically recognized diagnosis; a more accurate description is HPA axis dysregulation. The Adrenal Function Profile by Genova Diagnostics is a saliva-based test that measures your cortisol and DHEA levels throughout the day. It offers valuable insights into adrenal stress and the functional state of your HPA axis.

When to Consider This Test

Dysregulation of the HPA axis may contribute to a variety of symptoms and conditions, including:
• Allergies and sensitivities
• Anxiety, depression or PTSD
• Autoimmune diseases and low-grade inflammation
• Chemical sensitivity
• Chronic fatigue or exhaustion
• Chronic stress or burnout
• Decreased resilience and slow recovery after exercising
• Digestive problems and weakened immunity
• Hormonal imbalances (e.g., low libido, postpartum depression)
• Insulin resistance, prediabetes, or metabolic syndrome
• Irritability and mood swings
• Recurrent infections
• Sleep issues or disrupted circadian rhythm
• Sugar cravings, binge eating, or compulsive snacking
• Sympathetic dominance
• Weight gain (especially abdominal)

Price

The Adrenal Stress Profile is available for €155 (excluding shipping). Payment is made directly to the laboratory.

Ordering without a consultation

If you are already under the care of a physician or certified Functional Medicine practitioner, you may order this test through DNA Care without a consultation. A one-time processing fee of €50,- will apply. This includes about 45 minutes of dedicated time to request and process your order. You will receive clear instructions in advance, and your results will be securely delivered via Zorgmail, in full compliance with GDPR.

Professional Guidance at DNA Care

At DNA Care, we provide expert analysis and interpretation of your test results in the context of your symptoms and health history. If desired, we offer a personalized treatment plan grounded in the principles of Functional Medicine, focusing on nutrition, lifestyle, adrenal recovery, targeted supplementation, nervous system regulation, and epigenetic support.

Use the buttons below to view a sample test report or complete the order form. Once submitted, you will receive clear instructions by email.