DNA Core Analysis +

We are all unique. Who and what we are is largely determined by our genetic makeup, our DNA. How can we take care of our body in such a way that we have the best chance to live a healthy and vital life as long as possible? Whether you would like to lose weight, shape up or just feel healthier, your genetics hold valuable information about the best way to do this. Our DNA-analysis can help you find out where and how to start.

Are some of your genes creating these problems for you?

Brain and Mood Issues
• ADD/ADHD
• Anxiety
• Brain fog
• Depression
• Fatigue
• Insomnia and sleep disorders
• Irritability
• Memory problems

Cancer
• Breast cancer
• Ovarian cancer
• Stomach cancer

Cardiovascular Issues
• Atherosclerosis
• Hearts disease
• Hypertension
• Stroke
• Triglyceride elevation

Female Hormone Issues
• Menopause difficulties
• Menstrual challenges – cramps, excessive bleeding, mood and cognition difficulties
• Menstrual migraines
• PMS

Fertility and Pregnancy Issues
• Difficulty getting pregnant
• Difficulty carrying to term
• Increased risk of birth defects

Gland and Organ Issues
• Fatty liver and other liver dysfunction
• Gallstones
• Small intestine bacterial overgrowth (SIBO)
• Thyroid dysfunction

Metabolism Issues
• Food cravings, especially for sweets and carbs
• Obesity and weight gain

At DNA Care we support our clients by using insights from epigenetics to optimize health and wellbeing. We educate and guide our clients on how to overcome genetic dysfunction through diet, lifestyle, supplements and reducing physical, emotional and chemical stress. By understanding your genetic code, you can optimize your health, prevent and even reverse disease and live a full and vital life. 

We provide the necessary genetic testing for (hereditary) disease risk, prevention, healthy diet, weight control and sports performance. Results are unique, personal, scientifically and evidence based. Our DNA-analyses are designed for anyone looking to optimize their current and future health, vitality and sports performance through lifestyle adjustments, nutritional changes and supplements based on personalized information given by genetic variants.

Lifestyle
Healthy living is within your reach, starting today. Healthy living is a long-term commitment, but there are steps you can take right now that will make today healthier than yesterday and pave the way for healthy living tomorrow, too. So, what can you do to start living a healthy lifestyle? DNA Care can help you find out, based on your unique personal genetic profile.

Prevention
Health promotion engages and empowers individuals to engage in healthy behaviors and make changes that reduce the risk of developing chronic diseases.

Genetic Analysis would be good for anyone looking to optimize:
• Current health through lifestyle adjustments
• Future health thought lifestyle adjustments
• Nutritional changes
• Weight control
• Optimize sports performance
• Enhance your beauty
• Personalized micronutrient recommendations
(Based on personalized information given by genetic variants.)

All analyzed genes are scientifically proven, evidence based and double checked through other scientific studies.

DNA Core Analysis Test
DNA Core is the starting point on your journey to personalized healthcare. This test includes all gene variants tested and insights reported in DNA Health, DNA Diet, and DNA Sport, in one user-friendly report. This test reports on gene-environment interactions and provides personalized, easy-to-follow, summarized recommendations on four core areas:
• Key biological processes that drive health including methylation, detoxification and lipid metabolism.
• Macro- and micronutrient requirements based on genetic response.
• Weight management insights such as obesity risk and eating behavior.
• Exercise responsiveness including power and endurance potential and recovery time.

The following genes are tested:

Lipid Metabolism

• APOC3: Cholesterol metabolism.
• APOE: Catabolism of triglyceride-rich lipoprotein constituents. Affects antioxidant requirement.
• CETP: Metabolism of HDL and mediates the exchange of lipids between lipoproteins.
• LPL: Removes lipids from the circulation by hydrolyzing triglycerides into free fatty acids.
• PON1: Protects against atherogenesis by assisting in the cardioprotective effect of HDL.

Insulin Sensitivity

• PPARG: Involved in adipocyte differentiation and regulation of glucose and lipid metabolism.
• TCF7L2: Influences blood glucose homeostasis – both insulin secretion and resistance.
• SLC2A2: Facilitates glucose induced insulin secretion.
• FTO: Influences susceptibility to obesity and risk for type 2 diabetes.
• IRS1: Involved in transmission of insulin-based signals.

Methylation

• MTHFD1: Influences the effectiveness of the folate-dependent methylation pathway.
• MTHFR: Directs folate from the diet either to DNA synthesis or homocysteine remethylation.
• MTR: Catalyses the re-methylation of homocysteine to methionine.
• MTRR: Catalyses methylcobalamin, which is essential for maintaining adequate intracellular pools of methionine.
• CBS: Removal of homocysteine from the methionine cycle.
• COMT: Catalyses the transfer of a methyl group from S-adenosylmethionine to catecholamines.

Phase I Detoxification

• CYP1A1: Converts environmental pro-carcinogens into reactive intermediates that have carcinogenic effects.

Phase I Detoxification – Caffeine

• CYP1A2: Responsible for the demethylation of caffeine.

Phase II Detoxification

• GSTM1 & GSTP1: Responsible for the removal of xenobiotics, carcinogens, and products of oxidative stress.
• GSTT1: Catalyses the conjugation of reduced glutathione.
• NQO1: Detoxification of potentially mutagenic and carcinogenic quinones derived from tobacco smoke, diet and oestrogen metabolism.

Antioxidant Enzymes

• eNOS: Influences vascular tone and peripheral vascular resistance.
• MnSOD/SOD2: Vital antioxidant activity within the cell, especially within the mitochondria.
• GPx: Important selenium-dependent antioxidant enzymes.
• CAT: Responsible for the conversion of hydrogen peroxide to water and oxygen.

Inflammation

• CRP: Rises in response to inflammation in the body.
• IL-1A, IL-1B & IL-1RN: Important leverage points in the inflammatory cascade.
• IL-6 & IL-6R: Plays crucial roles in inflammation by regulating the expression of C reactive protein (CRP).
• TNFA: Crucial pro-inflammatory cytokine.

Vitamin D metabolism and Bone Health

• VDR: Profound influence on bone density.
• CYP2R1: Involved in the conversion of vitamin D to 25(OH)D (calcidiol).
• GC: Encodes for the vitamin D binding protein.

Vitamin A Metabolism

• BC01: Catalyzing carotenoids to retinal (vitamin A).

Vitamin B12 Transport

• FUT2: Vitamin B12 absorption and transport.

Lactose Intolerance

• MCM6: Associated with lactase persistence and adult hypolactasia.

Gluten Intolerance

• HLA DQ2/DQ8: Major genetic predisposition for coeliac disease.

Alcohol Metabolism

• ALDH2: Detoxification of toxic, carcinogenic aldehydes to acetate.

Iron Overload

• HFE: Major genetic predisposition for hemochromatosis.

Fat Absorption and Metabolism

• ADIPOQ: Regulates energy homeostasis and glucose tolerance thus promoting lipid oxidation in the muscle and liver.
• APOA2 & APOA5: Plays a complex role in lipoprotein metabolism, insulin resistance, obesity and atherosclerosis susceptibility.
• FABP2: Influences fat absorption and metabolism.
• PLIN: Influences diet-induced obesity.

Polyunsaturated Fatty Acid Metabolism

• FADS1: Key enzyme in polyunsaturated fatty acid (PUFA) metabolism.

Energy Homeostasis

• UCP1, UCP2 & UCP3: Involved in oxidative metabolism and energy production.

Epinephrine Receptors – Energy Mobilization

• ADRB2: Associated with blood vessel growth.
• ADBR3: Involved in the regulation of lipolysis that influences metabolism.

Dopamine Receptor

• DRD2: Important role in both addiction and normal eating behavior.

Taste Sensitivity

• TAS1R2 & TAS2R38: Contribute to inter-individual variations in sugar consumption and bitter sensitivity.

Snacking and Satiety

• MCR4: A strong obesity candidate gene.

Circadian Rhythms

• CLOCK: Effect on circadian rhythms and sleep duration.

Blood Flow and Respiration

• AGT & ACE: Part of the renin-angiotensin system and response to salt.
• BDKRB2: Influences the cross-talk between the renin-angiotensin and the kinin-kallikrein systems.
• VEGF: Affects peripheral circulation and capillary blood flow.

Energy During Exercise

• NRF-2: Improves respiratory capacity and increases ATP production.
• PPARGC1A: Mediation of the initial phase of exercise and increasing mitochondrial biogenesis.
• PPARA: Associated with lipid and glucose metabolism.

Fuel During Exercise

• TRHR: Stimulates the release of TSH.

Musculoskeletal Properties

• ACTN3: Influences the function of fast-twitch muscle fibres.

Muscle Cramping Susceptibility

• AMPD1: Muscle fatigue, weakness and cramping.

Collagen Production

• COL1A1 & COL5A1: Found in tendons, ligaments and cartilage.
• GDF5: Development and healing of the skeletal system and soft tissues.

Highest level of certification
Our laboratory is one of the leaders in genetic lifestyle-diagnostics and has a laboratory network of 100+ genetic laboratories with a portfolio of more than 3200 different medical genetic tests. Our laboratory is one of the most state-of-the-art and automated laboratories in Europe and has numerous certifications and quality assurance systems that meet or exceed the highest international standards.

Privacy policy
Your DNA and the original sample material are destroyed after 3 months, so that there are no names or other identifiers on the samples. The samples are analysed only for the SNP’s that are included in the tests at DNALife and no other research or analyses are performed without a separate written permission from the patient. The data are never sold to or shared with any third parties.

What are the costs of a DNA Core test?
The price of a DNA Core test is €309,-. This fee will be paid directly to the laboratory.

Can I request this test if I am not a client of DNA Care?
It is possible to request this test through DNA Care if you are not a client. In this case DNA Care will just charge you an administration fee. You will receive the test results as a PDF file via Zorgmail.

Which DNA-analysis is right for you?
Would you like to know which DNA-analysis would be right for you? Feel free to contact us with any questions you might have.